
If by "HOLY smokes," you mean
a derivative restatement of the stuff...
The Big Bang Theory Season 1, Episode 1

but I took a HOLY vow.
Game of Thrones Season 2, Episode 10

Unless, of course,
the Holy Spirit moves you.
The Big Bang Theory Season 1, Episode 4

Holy crap, Sheldon,
The Big Bang Theory Season 7, Episode 6

MRS. WOLOWITZ: Holy Moses,
how much liquid can be in one tuchus?
The Big Bang Theory Season 4, Episode 5